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Communication | Special issue | Vol 59, No. 1, 2003, pp.71-74
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S21
The Sonogashira Reaction in Water via an Amphiphilic Resin-supported Palladium-Phosphine Complex under Copper-free Conditions

Yasuhiro Uozumi* and Yukinari Kobayashi

*Institute for Molecular Science, Nishi-Gonaka 38, Myodaiji, Okazaki 444-8585, Japan


The Sonogashira reaction of aryl halides with terminal alkynes was catalyzed by an amphiphilic polystyrene-poly(ethylene glycol) (PS-PEG) resin-supported palladium-phosphine complex in water to give the corresponding aryl-substituted alkynes in high yields under copper-free conditions. Reaction of o-iodophenol with terminal alkynes under Sonogashira conditions gave benzofuran derivatives in one step.