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Paper | Special issue | Vol 59, No. 1, 2003, pp.207-215
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S20
Synthesis of Oligonucleotides with 6-Formyl-2’-O-Methyluridine and Thermal Stability of their Duplexes

Atsushi Kittaka,* Tetsuya Kuze, Akinori Sarai, Hiroaki Takayama, Hiromichi Tanaka, Tadashi Miyasaka, Jun-ichiro Inoue, and Shunsuke Ishii*

*Faculty of Pharmaceutical Sciences, Teikyo University, 1091-1 Suarashi, Sagamiko-machi, Tsukui-gun, Kanagawa 199-0195, Japan

Abstract

Single 6-formyl-2’-O-methyluridine or 2’-O-methyluridine was introduced into oligonucleotides (9-23 mers), which have simple base-sequences, as a substituent for thymidine to compare the ability of duplex formation and the thermal stability of the resulting duplexes.