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Paper | Special issue | Vol 59, No. 1, 2003, pp.115-128
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S2
A Simple One-Pot Synthesis of Benzoxazine-2,4-diones and Benzothiazine-2,4-diones

Xiaoxiang Zhu, Qian-sheng Yu, Nigel H. Greig,* Judith L. Flippen-Anderson, and Arnold Brossi

*Drug Design & Development Section, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging Intramural Program, National Institutes of Health, 5600 Nathan Shock Dr., Baltimore, MD 21224-6825, U.S.A.


A simple and efficient procedure has been developed for a one-pot synthesis of substituted benzoxazine-2,4-diones and benzothiazine-2,4-diones directly from salicylic acid (or thiosalicylic acid) and amines.