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Communication | Special issue | Vol 58, No. 1, 2002, pp.115-118
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S(M)49
Concise Syntheses of Harmicine and a Pyrrolidinoisoquinoline Derivative Using Chiral 1-Allyl Adducts of β-Carboline and Isoquinoline as Starting Materials

Takashi Itoh, Michiko Miyazaki, Kazuhiro Nagata, Masashi Yokoya, Shigeru Nakamura, and Akio Ohsawa*

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

Abstract

Total syntheses of (S)-harmicine and (R)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline were carried out using chiral 1-allyl-1,2,3,4-tetrahydro-β-carboline and 1-allyl-1,2-dihydroisoquinoline as starting materials, respectively.