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Paper | Regular issue | Vol 60, No. 6, 2003, pp.1307-1315
Published online, 14th April, 2003
DOI: 10.3987/COM-02-9701
Synthesis and Cytotoxic Activity of N-Acetylated Triindolylmethanes

Jun Li, Bing Guang, Liangbing Wang, Bogang Li, and Guolin Zhang*

*Chengdu Institute of Biology, The Chinese Academy of Sciences, Chengdu 610041, China

Abstract

Triindolylmethanes or N-acetylated triindolylmethanes were synthesized with high yields by treating indoles with indole-3-carboxaldehydes in acetic acid and acetic anhydride. In vitro screening showed that bis(indole-3- yl)-(N-acetylindole-3’-yl)methane (3a) and bis(2-methylindole-3-yl)-(N-acetyl- indole-3’-yl)methane (3b) possessed moderate cytotoxic activity against Lu-04 cell line with GI50 of 19 μM and 33 μM, respectively.