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Paper | Regular issue | Vol 60, No. 4, 2003, pp.879-886
Published online, 3rd March, 2003
DOI: 10.3987/COM-02-9698
Ethyl Vinyl Ether - an Agent for Protection of the Pyrazole NH-Fragment. A Convenient Method for the Preparation of N-Unsubstituted 4-Alkynylpyrazoles

Sergei F. Vasilevsky,* SvetlanaV. Klyatskaya, Eugene V. Tretyakov, and José Elguero*

*Instituto de Química Médica, C. S. I. C., Juan de Cierva, 3, E-28006 Madrid, Spain

Abstract

N-Unsubstituted 4-iodopyrazole (1) is easily converted into 4-alkynyl derivatives (5) in moderate to good overall yields by using intermediate protection of the nitrogen atom of the pyrazole ring by ethyl vinyl ether.