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Communication | Regular issue | Vol 60, No. 3, 2003, pp.519-522
Published online, 31st January, 2003
DOI: 10.3987/COM-02-9686
Formation of 3,4,5,6-Tetrahydro-7-hydroxy-6-methyl-1H-azepino[5,4,3-cd]indole in the Reaction of Serotonin with Acetaldehyde in Water in the Presence of Either L-Amino Acid, Nicotine or Fluoride

Masanori Somei* and Minoru Seto

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


Possible formation of a new compound, 3,4,5,6-tetrahydro-7-hydroxy-6-methyl-1H-azepino[5,4,3-cd]indole (4a), in serotonergic neuron after drinking ethanol is chemically suggested by reacting serotonin with acetaldehyde in water in the presence of either L-amino acid, nicotine or fluoride.