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Paper | Regular issue | Vol 60, No. 3, 2003, pp.583-598
Published online, 31st January, 2003
DOI: 10.3987/COM-02-9683
1-Methyl-3-trimethylsilylparabanic Acid as an Effective Reagent for the Preparation of N-Substituted (1-Methyl-2,5-dioxo-1,2,5H-imidazolin-4-yl)amines and Its Application to the Total Synthesis of Isonaamidines A and C, Antitumor Imidazole Alkaloids

Seikou Nakamura, Ikuo Kawasaki, Masayuki Yamashita, and Shunsaku Ohta*

*Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan


1-Methyl-3-trimethylsilylparabanic acid (17) was successfully used in the final step of the total synthesis of isonaamidine A (9), isonaamidine C (11) and pyronaamidine (8), antitumor marine imidazole alkaloids.