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Note | Regular issue | Vol 60, No. 3, 2003, pp.655-661
Published online, 20th January, 2003
DOI: 10.3987/COM-02-9678
New Oleanane-Type Triterpene Saponins from Millettia speciosa

Taketo Uchiyama, Masakatsu Furukawa, Sachi Isobe, Mitsuko Makino, Toshiyuki Akiyama, Tetsuo Koyama, and Yasuo Fujimoto*

*College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan

Abstract

The 70% ethanol extract of the roots of Millettia speciosa gave two new oleanane-type saponins along with two known pterocarpans, medicarpin and maackiain. The structures of new compounds were established on the basis of chemical and spectroscopic evidences. Medicarpin and maackiain showed cytotoxicity against leukemia cells (HL-60) and inhibited leukotrine secretion from RBL-2H3 cells.