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Paper | Regular issue | Vol 60, No. 3, 2003, pp.563-569
Published online, 31st January, 2003
DOI: 10.3987/COM-02-9670
One-Pot Dry Media Synthesis of New Tetracyclic 1,5-Benzothiazepines under Microwave Activation

Anshu Dandia,* Meha Sati, Kapil Arya, and André Loupy*

*Laboratoire des Réactions Sélectives sur Supports, ICMMO, CNRS UMR 8615, Université de Paris-Sud, Bâtiment 410, 91405 Orsay Cedex, France


Green chemical approaches to the condensation reaction of substituted benzenethiols and 2-arylidene-1-tetralone as synthons for the syntheses of a series of new 7-phenyl-5,6,6a,7-tetrahydrobenzo[b]naphtho[1,2-e][1,4]thiazepines (4a-e) of biological importance are described. The reaction using montmorillonite KSF as an inorganic solid is accelerated under microwave irradiation. Details and advantages of this new, efficient, solvent-free protocol along with non-thermal specific microwave effects are underlined.