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Note | Regular issue | Vol 60, No. 3, 2003, pp.607-613
Published online, 6th January, 2003
DOI: 10.3987/COM-02-9654
Synthesis and Identification of a Novel 6,5,6-Tricyclic Lactam

Joel P. Cooper,* Jeff E. Cobb, Barry G. Shearer, Douglas J. Minick, and Randy D. Rutkowske

*Department of Medicinal Chemistry, GlaxoSmithKline, Five Moore Drive, P.O. Box 13398, Research Triangle Park, North Carolina, 27709-3398, U.S.A.


While incorporating oxazoles into known PPARγ agonist an unexpected 6,5,6-tricylic lactam was isolated as the major product.