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Note | Regular issue | Vol 60, No. 2, 2003, pp.385-396
Published online, 16th December, 2002
DOI: 10.3987/COM-02-9635
Synthesis of 4-[4-(N,N-Dimethylsulfamoyl)piperazin-1-yl]quinolines Derivatives as Sorbitol Dehydrogenase Potential Inhibitors

Didier Varlet, Eric Fourmaintraux, Patrick Depreux,* and Daniel Lesieur

*Institut de Chimie Pharmaceutique, Albert Lespagnol, Université de Lille 2, 3, rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France


Synthesis of various quinolines, substituted in position 4 by [4-(N,N-dimethylsulfamoyl)piperazin-1-yl] group and in position 2 by different groups such as hydrogen, methyl, hydroxymethyl, formyl or carboxyl is described. Besides, we have synthesized derivatives of 8-hydroxyquinoline.