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Paper | Regular issue | Vol 60, No. 2, 2003, pp.309-319
Published online, 9th December, 2002
DOI: 10.3987/COM-02-9628
Chemistry of Indoles Carrying a Basic Function. Part VII. A New Aspect of Stobbe Reaction

István Moldvai, Eszter Temesvári-Major, Mária Incze, Tünde Platthy, Eszter Gács-Baitz, and Csaba Szántay*

*Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, H-1025 Budpest II, Pusztaszeri ut 59-67, P.O. Box 17, Hungary


While performing Stobbe reactions of a succinic diester derivative (1) different routes were found leading to different indole derivatives (2-5) depending on the reaction conditions applied, thus widening the scope and limitation of this useful procedure. Simpler pyrrolidine (13) and piperidine derivatives (14, 15) were also achieved through application of the intramolecular Stobbe reaction.