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Paper | Regular issue | Vol 57, No. 12, 2002, pp.2321-2334
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9620
An Efficient Synthesis of N-Alkyl-4-substituted-3H-pyridine-2,6-dione. Synthesis of Isoguvacine and MDL-11,939

Meng-Yang Chang, Shui-Tein Chen,* and Nein-Chen Chang

*Institute of Biological Chemistry, Academia Sinica, 128, Yan-Chiu-Yuan Road, Sec II, NanKang, Taipei, 11529, Taiwan, R.O.C.


An efficient route towards the synthesis of N-alkyl-4-substituted 3H-pyridine-2,6-dione using various N-alkyl-α-sulfonylacetamides and two α,β-unsaturated esters as starting materials is described. Isoguvacine and MDL-11,939 with have potential biological activities were synthesized via this strategy.