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Note | Regular issue | Vol 57, No. 12, 2002, pp.2401-2408
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9615
Phenanthroindolizidine Alkaloids and Their Cytotoxicity from the Leaves of Ficus septica

Pei-Lin Wu,* K. V. Rao, Chia-Hao Su, Cheng-Sheng Kuoh, and Tian-Shung Wu*

*Department of Chemistry, Natioanl Cheng Kung University, Tainan, 70101, Taiwan, R.O.C.


Phenanthroindolizidine N-Oxide, ficuseptine-A (1), together with eighteen known compounds was isolated from the leaves of Ficus septica. The structures of these compounds were elucidated by spectroscopic analysis. Among them, phenanthroindolizidines, ficuseptine (1), (+)-tylophorine (4) and a mixture of (+)-tylocrebrine (5) and (+)-isotylocrebrine (6), exhibited strong cytotoxic activity against two human cancer cell lines, NUGC and HONE-1.