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■ A New Synthesis of 6-Substitiuted Pyrido[2,3-d]pyrimidines

Takeshi Kuwada, Kenichi Harada, Junko Nobuhiro, Tominari Choshi, and Satoshi Hibino*

*Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan

Abstract

The reaction of the β-methylsulfanylacroleins, derived from alkenyl sulfides by the Vilsmeier reaction, with 6-aminouracils or 2,6-diaminouracil, provides a new synthetic route to the 6-substituted pyrido[2,3-d]pyrimidines by two methods, the reaction mechanisms of which were examined by a deuterium-labeled thioacrolein.