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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Note | Regular issue | Vol 57, No. 10, 2002, pp.1907-1914
Published online, 1st January, 1970■ Synthesis of Dihydrothiophene Derivatives as Metabolites of Esonarimod
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9549
■ Synthesis of Dihydrothiophene Derivatives as Metabolites of Esonarimod
Toshiya Noguchi,* Akira Onodera, Kazuyuki Tomisawa, and Sadakazu Yokomori
*Process Chemistry Latoratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-Cho, Saitama-city, Saitama 330-8530, Japan
Abstract
Three compounds with a dihydrothiophene ring were synthesized as authentic samples to analyze human metabolites of Esonarimod, which has been developed as a new antirheumatic drug.
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