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Note | Regular issue | Vol 57, No. 10, 2002, pp.1907-1914
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9549
Synthesis of Dihydrothiophene Derivatives as Metabolites of Esonarimod

Toshiya Noguchi,* Akira Onodera, Kazuyuki Tomisawa, and Sadakazu Yokomori

*Process Chemistry Latoratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-Cho, Saitama-city, Saitama 330-8530, Japan


Three compounds with a dihydrothiophene ring were synthesized as authentic samples to analyze human metabolites of Esonarimod, which has been developed as a new antirheumatic drug.