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Paper | Regular issue | Vol 57, No. 11, 2002, pp.1997-2010
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9545
A New Synthesis of Substituted 2,5-Dihydrobenzo[b]oxepines

Eng-Chi Wang,* Ming-Kun Hsu, Yu-Li Lin, and Keng-Shiang Huang

*School of Chemistry, aohsiung Medical University, 100 Shin Chuen 1st Rd., Kaohsiung 80708, Taiwan, R.O.C.


Based on Claisen rearrangement, Baeyer-Villiger oxidation, and ring-closing metathesis (RCM), a series of substituted 2,5-dihydrobenzo[b]oxepines were synthesized from isovanillin in good over-all yields. Other appropriate substituted 2,5-dihydrobenzo[b]oxepines prepared from corresponding phenol derivatives were also described.