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Note | Regular issue | Vol 57, No. 9, 2002, pp.1683-1688
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9523
Convenient Preparation of Tacrine Derivatives by the Reduction of 9-Aminoacridines with Nickel-aluminum Alloy

Kichinosuke Kamata,* Yoh-ichi Tominaga, Akiyoshi Tori-i, Thies Thiemann, Kazufumi Takahashi, and Shuntaro Mataka*

*Instituete of Advanced Material Study, Kyushu University, 6-1, Kasuga-koen, Kasuga 816-8580, Japan


9-Amino-1,2,3,4-tetrahydro- and 9-amino-1,2,3,4,5,6,7,8-octahydro-acridine derivatives (2 and 3) were conveniently prepared in the reduction of the corresponding 2-substituted 9-aminoacridines (1a-f) with nickel-aluminum alloy under basic conditions. The reduction is dependent upon the nature of the substituent in the 2-position of the starting 9-aminoacridines.