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Note | Regular issue | Vol 57, No. 6, 2002, pp.1143-1148
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9489
An Efficient Synthesis of N-Boc-D-diphenylalanine from a Chiral Azirdine-2-carboxylate

Jae-Won Chang, Hyun-Joon Ha,* Chan Sun Park, Min Sung Kim, and Won Koo Lee*

*Department of Chemistry, Hankuk University of Foreign Studies, Yongin, Kyunggi-Do, 449-791, Korea

Abstract

N-Boc-D-diphenylalanine was prepared from a commercially available aziridine-2(S)-carboxylate through alkylation, regiospecific aziridine ring opening, and benzylic deoxygenation followed by oxidation in 57% overall yield.