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Note | Regular issue | Vol 57, No. 7, 2002, pp.1287-1292
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9483
Two New Pyranoflavanones from the Stems Derris reticulata

Chulabhorn Mahidol, Hunsa Prawat, Wirongrong Kaweetripob, and Somsak Ruchirawat*

*Laboratory of Medicinal Chemistry, Chulabhorn Reseach Institute, Vipavadee-Rangsit Highway, Bangkok 10210, Thailand

Abstract

Two new flavonoids, 4’,5-dihydroxy-8-hydroxymethyl-6’’,6’’-dimethylpyrano[2’’,3’’:7,6]flavanone (1), and 2’’,3’’-dihydroxylupinifolin (2) were isolated from the stems of Derris reticulata. Both compounds showed cytotoxic activity in the P-388 cell line. The structures were established by spectroscopic analysis and chemical transformations. The biosynthetic origin and the mechanism of formation of the hydroxymethyl group in compound (1) are proposed.