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Note | Regular issue | Vol 57, No. 10, 2002, pp.1869-1879
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9478
1H NMR Evidence of C–H---O, C–H---N and C–H---Cl Hydrogen Bonds in New Thiazole Derivatives

Francisco Sánchez-Viesca* and Martha Berros

*Faculty of Chemistry, Postgrade Division, National Autonomous University, University City, 04510, Mexico, D.F.


A comparative study of the chemical shift differences observed in the 1H NMR spectra of a series of fifteen new polysubstituted 4-aryl- and 2,4-diaryl thiazoles permitted us to establish two groups of rotamers. Some present paramagnetic shifts due to intramolecular weak hydrogen bonding and this was confirmed by experiments “at infinite dilution”, single crystal X-Ray studies, NOESY and HMBC experiments.