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Note | Regular issue | Vol 57, No. 6, 2002, pp.1135-1141
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9461
The Reactions of Hydroiodide of 2-Amino-1-substituted Guanidine Derivatives with Aromatic Isothiocyanates

Maria Dobosz* and Monika Wujec

*Department of Organic Chemistry, Faculty of Pharmacy, Medical University in Lublin, 6 Staszica Str., 20-081 Lublin, Poland


In the reaction of hydroiodide of methyl ester of S-methylthio- semicarbazide with primary amines hydroiodides of 2-amino-1-substitutedguanidine were obtained (1). These compounds were then converted to respective 3-arylamino-4-substituted Δ2-1,2,4-triazoline-5-thione and 3-benzylamino-4-substituted Δ2-1,2,4-triazoline-5-thione (2) in the reactions with isothiocyanates.