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Communication | Special issue | Vol 56, No. 1-2, 2002, pp.39-43
Published online, 1st January, 1970
DOI: 10.3987/COM-01-S(K)8
A New Route to (-)-Aphanorphine Using a Dioxabicyclo[3.2.1]octane Chiral Building Block

Adel S. ElAzab, Takahiko Taniguchi, and Kunio Ogasawara*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


A new stereocontrolled route to (-)-aphanorphine, isolated from the fresh-water blue-green algae Aphanizomenon flos-aquae has been developed by using a chiral building block having a dioxabicyclo[3.2.1]octane framework and originally designed for the construction of the aldohexose molecules.