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Paper | Special issue | Vol 56, No. 1-2, 2002, pp.369-377
Published online, 1st January, 1970
DOI: 10.3987/COM-01-S(K)50
New Solid-supported Reagents (SSRs) for Selective Acylation of Amines

Maurizio Botta,* Federico Corelli,* Elena Petricci, and Catia Seri

*Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, A. Moro-53100 Siena, Italy


The pyrimidine linker (4) was prepared by solid phase synthesis starting from Merrifield resin. Acylation of 4 with different acyl chlorides gave polymer-bound 4-acyloxypyrimidines (2a-c), which proved to be useful solid-supported reagents for the selective acylation of amines. Their use in solution combinatorial chemistry has been also envisaged.