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Communication | Special issue | Vol 56, No. 1-2, 2002, pp.45-50
Published online, 1st January, 1970
DOI: 10.3987/COM-01-S(K)10
Antiinflammatory Principles and Three New Labdane-Type Diterpenes, Hedychilactones A, B, and C, from the Rhizome of Hedychium coronarium Koeng

Hisashi Matsuda, Toshio Morikawa, Yasuko Sakamoto, Iwao Toguchida, and Masayuki Yoshikawa*

*Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan

Abstract

Three new labdane-type diterpenes named hedychilactones A, B, and C were isolated from the methanolic extract of the fresh rhizome of Hedychium coronarium KOENG. Their structures were elucidated on the basis of chemical and physicochemical evidence, which included the application of the allylic benzoate rule. The methanolic extract and diterpene constituents were found to inhibit the increase of vascular permeability induced by acetic acid in mice and nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages.