Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 57, No. 3, 2002, pp.523-528
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9427
Synthesis and Structural Assignment of Functionalized 8,9-Diazatricyclo[,5]decane: A New Tricyclic System Including the Pyridazine Ring

Xavier Cachet, Brigitte Deguin, François Tillequin,* Michel Koch, and Angèle Chiaroni

*Laboratoire de Pharmacognosie,UMR 8638 associee au CNRS, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, 4, Avenue de l'Observatoire, 75270 Paris Cedex, France


Reaction of hydrazine hydrate with the dipivaloyl ester of (1S, 4R, 5R, 6R)-4-hydroxy-2-hydroxymethyl-1-formylbicyclo[3.1.0]hex-2-ene-6-carboxylic acid (2) afforded (1S, 2R, 4R, 5R, 6R)-8,9-diaza-2-[(2,2-dimethylpropanoyloxy)methyl]-7-oxotricyclo[,5]dec-9-en-4-yl 2,2-dimethylpropanoate (3). The structure and conformation of the new 8,9-diazatricyclo[,5]dec-9-ene system were determined by X-Ray cristallography and 2D NMR experiments.