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Note | Regular issue | Vol 57, No. 3, 2002, pp.515-522
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9409
Design and Synthesis of a Novel Cyclophane as Host for Aryl Phosphate

Muneharu Miyake* and Craig S. Wilcox

*College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan


A novel Tröger base derived cyclophane bearing mercaptoimidazole groups on the alkyl chains as blanches of 6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine skeleton was synthesized in order to investigate the ability as macrocyclic enzyme models to incorporate phosphotyrosine in future.