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Note | Regular issue | Vol 57, No. 2, 2002, pp.337-340
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9399
The Absolute Configuration of Leiocarpin B

Qing Mu, Weidong Tang, Chaoming Li, Yongping Xu, Handong Sun, Liguang Lou, Xiaojiang Hao,* Bin Xu, and Chang Qi Hu

*Laboratory of Phytochemistry, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, Yunnan 650204, China

Abstract

Leiocarpin B, a natural compound isolated from the plant, Goniothalamus leiocarpus, is a styryllactone showing anticancer activity in vitro test. Its chemical structure and relative configuration were determined by means of spectral methods and X-Ray crystallographic analysis. In the present investigation, its absolute configuration was determined using the Mosher’s method and its anticancer activities were tested in vivo.