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Note | Regular issue | Vol 57, No. 2, 2002, pp.327-336
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9391
Formal Total Synthesis of Macrosphelide (+)-A, Effect on Marcolactonization Depended upon the Lactone Formation Position

Hiroshi Nakamura, Machiko Ono, Miho Makino, and Hiroyuki Akita*

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

Formal total synthesis of (+)-macrosphelide A (1) was achieved based on macrolactonization via path B from a seco-acid (3) and path C from a seco-acid (4). The yield of macrolactonization via paths B and C were 18 and 59%, respectively.