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Communication | Regular issue | Vol 57, No. 1, 2002, pp.5-10
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9381
Heterocyclizations towards 2-Arylbenzimidazoles via Intermolecular Coupling of 2-Nitroanilines and Aryl Aldehydes

Byeong Hyo Kim,* Rongbi Han, Tae Hee Han, Young Moo Jun, Woonphil Baik, and Byung Min Lee

*Department of Chemistry, Kwangwoon University. 447-1, Wolgye-Dong Nowon-ku, Seoul, 139-701, Korea

Abstract

The reductive intermolecular coupling/heterocyclization reaction between 2-nitroaniline and aromatic aldehydes towards 2-substituted and 1,2-disubstituted benzimidazoles was accomplished in the presence of 2-bromo-2-nitropropane/Zn in a MeOH/CH2Cl2 solution at room temperature.