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Communication | Regular issue | Vol 55, No. 12, 2001, pp.2279-2282
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9356
Novel and Efficient Synthesis of 8-Oxoadenine Derivatives

Kosaku Hirota,* Kazunori Kazaoka, Itaru Niimoto, and Hironao Sajiki

*Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan


A novel synthetic method of 8-oxoadenine derivatives (3 and 4) is reported. This widely applicable synthetic method was realized through the use of 5-amino-4-cyano-2-oxoimidazole derivatives (2) as the key intermediates. A variety of substituents were successfully introduced to the 2- and 9-position of the 8-oxoadenine nucleus.