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Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Communication | Regular issue | Vol 55, No. 12, 2001, pp.2279-2282
Published online, 1st January, 1970■ Novel and Efficient Synthesis of 8-Oxoadenine Derivatives
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9356
■ Novel and Efficient Synthesis of 8-Oxoadenine Derivatives
Kosaku Hirota,* Kazunori Kazaoka, Itaru Niimoto, and Hironao Sajiki
*Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan
Abstract
A novel synthetic method of 8-oxoadenine derivatives (3 and 4) is reported. This widely applicable synthetic method was realized through the use of 5-amino-4-cyano-2-oxoimidazole derivatives (2) as the key intermediates. A variety of substituents were successfully introduced to the 2- and 9-position of the 8-oxoadenine nucleus.
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