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Communication | Regular issue | Vol 55, No. 11, 2001, pp.2043-2050
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9318
■ Javaberine A, New TNF-α and Nitric Oxide Production Inhibitor, from the Roots of Talinum paniculatum

Hiroshi Shimoda, Norihisa Nishida, Kiyofumi Ninomiya, Hisashi Matsuda, and Masayuki Yoshikawa*

*Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan

Abstract

The methanolic (MeOH) extract from the roots of Talinum paniculatum was found to exhibit inhibitory activities on the lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α and nitric oxide (NO) production from mouse peritoneal macrophages, and on the TNF-α production from rat epididymal adipose tissue. From the MeOH extract, two new 8-benzyltetrahydro-protoberberine–type alkaloids, named javaberines A and B, were isolated and their structures were elucidated on the basis of chemical and physicochemical evidence. The principal alkaloid, javaberine A, inhibited LPS-induced TNF-α and NO production from mouse peritoneal macrophages and TNF-α production from rat epididymal adipose tissue.