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Paper | Regular issue | Vol 55, No. 9, 2001, pp.1727-1735
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9278
12H-[2]-Benzothiepino[6,5a,5-bc]benzofuran: Synthesis of a Sulfur-Analog of Galanthamine

Matthias Treu, Ulrich Jordis,* and Kurt Mereiter

*Institute of Organic Chemistry, Vienna University of Technology, Getreidemarkt 9/154, A-1060 Vienna, Austria


An analog of the anti-Alzheimer drug galanthamine, carrying a SO2-moiety instead of an amino-functionality, has been synthesized as a racemic mixture using tandem cyclization techniques to form a new four membered heterocyclic ring system.