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■ Medicinal Foodstuffs. XXVI. Inhibitors of Aldose Reductase and New Triterpene and Its Oligoglycoside, Centellasapogenol A and Centellasaponin A, from Centella asiatica (Gotu Kola)

Hisashi Matsuda, Toshio Morikawa, Hiroki Ueda, and Masayuki Yoshikawa*

*Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan

Abstract

The methanolic extract from the aerial parts of Centella asiatica L. cultivated in Vietnam was found to inhibit rat lens aldose reductase. From the methanolic extract, a new olean-13-ene-type triterpene, centellasapogenol A, and its oligoglycoside, centellasaponin A, were isolated together with several known saponins and flavonoids. Their structures were elucidated on the basis of chemical and physicochemical evidence. In addition, a flavonol component, petuletin, was found to show potent inhibitory activity on aldose reductase.