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■ Application of Hexamethylenetetramine in a Pictet-Spengler Type Reaction for Synthesis of Isoquinoline Derivatives

Iliyan Ivanov and Atanas Venkov*

*Department of Organic Chemistry, University of Plovdiv, 24, Tsar Assen Str. 4000 Plovdiv, Bulgaria

Abstract

Hexamethylenetetramine was used successfully as amino- and amidoalkylation cyclization reagent for the synthesis of 3,4-dihydroisoquinolines, tetrahydroisoquinolines and 1,4-dihydro-3(2H)-isoquinolinones. The reagent provides a simple and convenient pathway for the preparation of a range of these compounds.