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Note | Regular issue | Vol 55, No. 8, 2001, pp.1555-1559
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9244
A Simple Synthesis of Rutaecarpine

Seung Ho Lee, Seung Ill Kim, Jae Gyu Park, Eung Seok Lee, and Yurngdong Jahng*

*College of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea

Abstract

Indoloquinazoline alkaloid rutaecarpine was efficiently synthesized by employing 9,10,11,12-tetrahydro-4H-pyrido[2,1-b]quina-zoline-4,9-dione as a key intermediate, whose 9-carbonyl group was introduced by benzylidene formation, followed by ozonolysis.