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Paper | Regular issue | Vol 55, No. 7, 2001, pp.1263-1270
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9216
Inhibition of HIV Integrase by 4-Hydroxycoumarin Dimer Bearing Aniline Mustard Moiety

Pili Chih-Min Mao, Jean-Francois Mouscadet, Herve Leh, Christian Auclair, and Ling-Yih Hsu*

*School of Pharmacy, National Defense Medical Center, P.O. Box 90048-508, Neihu, Taipei, Taiwan, R.O.C.

Abstract

The design, synthesis of novel HIV-integrase (HIV-IN) inhibitors possessing the 4-hydroxycoumarin dimer bearing aniline mustard moiety are described. These compounds showed good inhibitory activity against HIV-IN.