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Note | Regular issue | Vol 55, No. 7, 2001, pp.1347-1363
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9215
Quinone-cyclized Porfiromycins

Younghwa Na and Harold Kohn*

*Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, U.S.A.


Mitomycin C and porfiromycin cyclization has been implicated in the pathway for KW-2149 and BMS-181174 function. The importance of the porfiromycin C(7) structure and nucleophile for quinone cyclization was determined showing that both C(7) and C(8) annulation processes occur.