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Note | Regular issue | Vol 55, No. 7, 2001, pp.1315-1321
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9209
A One-Pot Synthesis of Pyrido[2,3-d]- and Quinolino[2,3-d]pyrimidines

Abdel Aziz S. El-Ahl,* Serry A. A. El Bialy, and Mohamed A. Ismail

*Department of Chemistry, Faculty of Science, University of Mansoura, Mansoura, Egypt


The in situ formed methylene derivatives of 1,3-dicarbonyl compounds; ethyl cyanoacetate; malononitrile and ketones; react with 6-amino-1,3-dimethyluracil as activated alkenyl derivatives, affording Michael adducts. The adduts simultaneously undergo cyclization to furnish pyrido[2,3-d]- or quinolino[2,3-d]pyrimidine derivatives in high yield.