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Paper | Regular issue | Vol 55, No. 7, 2001, pp.1253-1261
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9196
Stereoselective Synthesis of a Novel Tetracyclic β-Lactam

Do Kyu Pyun, Hee Jung Jung, Hyun Jung Kwak, Jae Hak Kim, Eun Jung Kim, Bong Jin Kim, Moon Hwan Kim, and Cheol Hae Lee*

*Pharmaceutical Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yusung, Taejon 305-343, Korea


Stereocontrolled total synthesis of a novel tetracyclic β-lactam (3) has been achieved in ten steps. The key transformations in this approach are the regioselective ring opening of β-epoxide () and the stereoselective construction of ketoazetidinone (11) from methoxyketo-γ-lactam (9) and 4-acetoxyazetidinone (10).