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Note | Regular issue | Vol 55, No. 6, 2001, pp.1147-1149
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9194
An Improved Hydrolysis of 7α-Chloro-7β-cyano-6,14-endo-ethenotetrahydrothebaine to Its 7-Oxo Derivative

Dean Y. Maeda and Andrew Coop*

*Department of Pharmceutcial Sciences, School of Pharmacy, University of Maryland, 20 Norht Pine Street, Baltimore, MD 21201, U.S.A.


An efficient method for the conversion of 7α-chloro-7β-cyano-6,14-endo-ethenotetrahydrothebaine (4) to 6,14-endo-etheno-7-oxotetrahydrothebaine (3) using Na2S·9H2O is described. This method requires no chromatography for purification, and is therefore amenable to large scale preparation of the potentially important opioid intermediate.