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Paper | Regular issue | Vol 55, No. 5, 2001, pp.925-940
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9181
A Straightforward Synthesis of Pyridopyrazino[2,3-b]indoles and Indolo[2,3-b]quinoxaline

France-Aimée Alphonse, Sylvain Routier, Gérard Coudert, and Jean-Yves Mérour*

*Institut de Chimie Organique et Analytique, UMR CNRS 6005, BP 6759, Université d'Orléans, Rue de Chartres, 45067 Orléans Cédex 2, France


1,2-Diamines (ethylenediamine, o-phenylenediamine, 2,3-diaminopyridine, 3,4-diaminopyridine) were reacted with 1-acetyl-2-bromo-3-indolinone to afford 5H-pyrazino[2,3-b]indoles, indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole in good yields. Alkylation of the indolic nitrogen atom of these indolic derivatives with 2-chloroethylmorpholine, 2-chloroethyldimethylamine and allyl bromide was carried out in order to obtain the corresponding N-alkylated derivatives.