Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 55, No. 5, 2001, pp.925-940
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9181
A Straightforward Synthesis of Pyridopyrazino[2,3-b]indoles and Indolo[2,3-b]quinoxaline

France-Aimée Alphonse, Sylvain Routier, Gérard Coudert, and Jean-Yves Mérour*

*Institut de Chimie Organique et Analytique, UMR CNRS 6005, BP 6759, Université d'Orléans, Rue de Chartres, 45067 Orléans Cédex 2, France

Abstract

1,2-Diamines (ethylenediamine, o-phenylenediamine, 2,3-diaminopyridine, 3,4-diaminopyridine) were reacted with 1-acetyl-2-bromo-3-indolinone to afford 5H-pyrazino[2,3-b]indoles, indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole in good yields. Alkylation of the indolic nitrogen atom of these indolic derivatives with 2-chloroethylmorpholine, 2-chloroethyldimethylamine and allyl bromide was carried out in order to obtain the corresponding N-alkylated derivatives.