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Paper | Regular issue | Vol 55, No. 5, 2001, pp.889-903
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9171
Synthesis of cis- or trans-2,4-Disubstituted Tetrahydrofurans Bearing Amino and Imidazole Groups by Efficient Use of the Modified or Standard Mitsunobu Cyclization: Synthetic Studies toward Novel Histamine H3-Ligands

Lisa Araki, Shinya Harusawa, Ikuno Ijichi, Hirofumi Ohishi, and Takushi Kurihara*

*Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan


4(5)-[(2R,4S) or (2S,4S)-4-Aminotetrahydrofuran-2-yl]imidazole [(-)-1a or (-)-1b] and its enantiomers [(+)-2a and (+)-2b] were synthesized by efficient use of the modified or standard Mitsunobu cyclization.