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Paper | Regular issue | Vol 55, No. 5, 2001, pp.881-888
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9169
Reaction of 3-Iodochromone with Nucleophiles 3. Formation of 2-Aminomethylene-3(2H)-benzofuranones by the Reaction with Secondary Amines

Yoshiaki Sugita,* Takako Iwaki, Misaki Okamoto, and Ichiro Yokoe*

*Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan

Abstract

3-Iodochromone (4a) easily reacted with secondary amines in the presence of potassium carbonate to give 2-aminomethylene-3(2H)-benzofuranones in good yields. Under similar conditions without potassium carbonate, 4a was reacted with piperidine to give the enamino ketone (5) as the major product.