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Communication | Regular issue | Vol 55, No. 4, 2001, pp.635-640
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9167
Synthesis of 4-Aryltetrahydroiso-quinolines: Application to the Synthesis of Cherylline

Somsak Ruchirawat,* Sopchok Tontoolarug, and Poolsak Sahakitpichan

*Labotratory of Medicinal Chemistry, Chulabhorn Reseach Institute, VipavadeeÅ@Rangsit Highway, Bangkok 10210, Thailand

Abstract

A concise route for the synthesis of 4-aryltetrahydroisoquinolines was developed using the addition of Grignard reagents to nitrostyrene derivatives as the key step. The application to the synthesis of cherylline was described.