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Note | Special issue | Vol 56, No. 1-2, 2002, pp.457-466
Published online, 1st January, 1970
DOI: 10.3987/COM-00-S(K)1
New Chiral Pyrrolidinyl- and 2-Azanorbornyloxazolidine Ligands for Enantioselective Addition of Diethylzinc to Aldehydes

Hiroto Nakano,* Yuko Okuyama, Kazuyuki Fushimi, Ryo Yamakawa, Daisuke Kayaoka, and Hiroshi Hongo*

*Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

Abstract

A new type of optically active ligands, pyrrolidinyl- (3a-c) and 2-azanorbornyloxazolidines (6a-d) were synthesized and their abilities as ligands were examined in the enantioselective addition of diethylzinc to aromatic and aliphatic aldehydes to give optically active secondary alcohols of up to 83% ee.