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Communication | Special issue | Vol 54, No. 2, 2001, pp.607-610
Published online, 1st January, 1970
DOI: 10.3987/COM-00-S(I)91
Synthesis of a Novel Artemisinin Analogue Having Potent Antimalarial Activity

Kiyosei Takasu,* Ruriko Katagiri, Yuko Tanaka, Masahiro Toyota, Hye-Sook Kim, Yusuke Wataya, and Masataka Ihara*

*Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan


An artemisinin analogue containing 1,2,4-trioxane structure was designed and synthesized. The compound exhibited significant and selective in vitro antimalarial activity