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Communication | Special issue | Vol 54, No. 1, 2001, pp.105-108
Published online, 1st January, 1970
DOI: 10.3987/COM-00-S(I)63
A Practical Route to Quinolines from Anilines

Hidetoshi Tokuyama, Masashi Sato, Toshihiro Ueda, and Tohru Fukuyama*

*Graduate School of Pharmaceutical Sciences, University of Tokyo, CREST, The japan Science and Technology Corporation (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan


A practical route to quinoline from anilines through acid-mediated cyclization of 3-(N-aryl-N-sulfonylamino)propionaldehydes has been developed. Treatment of the cyclization products, dihydroquinoline intermediates with KOH in DMSO leads to substituted quinolines.