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Paper | Special issue | Vol 54, No. 2, 2001, pp.721-726
Published online, 1st January, 1970
DOI: 10.3987/COM-00-S(I)49
The Identification, Mechanism, and Improved Synthesis of a New and Unique Heterocyclic System with a Fused Imidazole Ring

Isamu Katsuyama, Ashraf A. Khalil, Jianwei Ren, and Jordan K. Zjawiony*

*Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Science, School of Pharmacy, The University of Mississippi, University, MS 38677-1848, U.S.A.


The reaction of sampangine (1) with arylalkylamines resulted in unexpected formation of a new and unique sampangine derivative with a fused imidazole ring (3). The identification and formation mechanism of 3, as well as its improved synthesis, are described.